Progress in reducing tobacco use is a key indicator for measuring countries’ efforts to implement the WHO Framework Convention on Tobacco Control. Countries have adopted this indicator to report progress towards SDG target 3.a and the tobacco reduction target under the Global Action Plan for the Prevention and Control of Noncommunicable Diseases 2013–2020. This report presents WHO estimates of tobacco use prevalence, numbers or users, and changes between 2000 and 2018, projected to 2025. Estimates are at global, regional and country level.